Laminin Pentapeptide(929-933)

描 述：The pentapeptide YIGSR located within domain III of the laminin B1 chain, represents a major receptor binding site in laminin. By competing with laminin for the cell surface receptor, the short peptide is able to inhibit cell attachment to basement membranes, thus preventing the formation of tumor metastases. YIGSR also promotes tumor cell migration and, moreover, mediates the adhesion of a variety of epithelial cells to laminin.

五肽 YIGSR 位于层粘连蛋白 B1 链的域 III 内，代表层粘连蛋白中的主要受体结合位点。通过与层粘连蛋白竞争细胞表面受体，短肽能够抑制细胞对基底膜的附着，从而防止肿瘤转移的形成。YIGSR 还促进肿瘤细胞迁移，此外，还介导多种上皮细胞与层粘连蛋白的粘附