CRF, bovine (TFA) 是一种有效的CRF受体激动剂，能够取代 [125I-Tyr]ovine CRF，Ki 值为 3.52 nM。

体外研究：

CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. CRF shows pEC50s of 11.16, 8.53 and 8.70 for human CRF1, human CRF2 and rat CRF2α[2]. CRF is released from hypothalamic-pituitary-adrenal (HPA) axis induced by stress, and leads to production of glucocorticoids which down regulate immune responses. CRF also has proinflammatory effects. CRF affects brain microvessel endothelial cells (BMEC) structure or function, CRF (100 nM) significantly increases cAMP in BMEC[3].

单字母 H2N-SQEPPISLDLTFHLLREVLEMTKADQLAQQAHNNRKLLDIA-CONH2
多字母 H2N-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Asn-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-CONH2
氨基酸个数 41
分子式 C206H340N60O63S1
平均分子量(MW) 4697.33
精确分子量(Exact Mass)(MW) 4694.5
等电点(PI) 6.51
pH=7.0时的净电荷数 -0.55
GRAVY -0.39
亲水残基比例 0.07
消光系数 -
溶解建议 亲水