RIPK1-IN-12 是一种有效的RIPK1抑制剂，RIPK1-IN-12能抑制人和小鼠细胞的坏死性凋亡，EC50 值分别为 1.6 和 2.9 nM.

RIPK1-IN-12 (Compound 58; 24 hours) demonstrates potent anti-necroptotic activity (EC50=1.6 nM in HT-29 cells and EC50= 2.9 nM in L929 cells)[1].

CAS No. : 2173556-92-6

参考文献：

Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity【 DOI: 10.1016/j.ejmech.2021.114036】