PAR-4 Agonist Peptide, amide TFA

同义词：PAR-4-AP TFA; AY-NH2 TFA

分子量：794.82
分子式：C36H49F3N8O9
CAS 号：1228078-65-6
三字母：Ala-Tyr-Pro-Gly-Lys-Phe-NH2

单字母：AYPGKF-NH2

产品描述：

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) 是一种蛋白酶激活受体-4 (PAR-4) 激动剂，对 PAR-1 或 PAR-2 都没有作用，且其作用会被 PAR-4 拮抗剂阻断。

体内研究：

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)。